Longevity Supplement Stack
Supplement Protocol · 13 interventions
Sinclair's NAD+/sirtuin-focused supplement and prescription protocol. Core thesis: activate survival pathways through NMN, resveratrol, and fasting mimetics.
01Interventions
Supplements
10 interventions- 01Dose & timing1g Daily · Morning, mixed in yogurt
NAD+ precursor — fuels sirtuins for DNA/epigenome repair
- 02Dose & timing1g Daily · Morning, with fat (yogurt) for absorption
Sirtuin activator — "accelerator pedal" for sirtuin genes
- 03Dose & timing500-1,000 mg Daily
Methyl donor — counteracts methylation depletion from NMN
- 04Dose & timing1-2 mg Daily · Morning
Autophagy activator — cellular renewal
- 05Dose & timing500 mg Daily · Morning
Senolytic — clears senescent cells, anti-inflammatory
- 06
- 07
- 08
- 09
- 10Dose & timing83 mg Daily
Anti-inflammatory, potential cancer risk reduction
Medications
3 interventions- 11Dose & timing800-1,000 mg Daily · Evening
Fasting mimetic — AMPK activation, metabolic support
- 12Dose & timingDose unspecified Daily
Genetically high cholesterol — on statins since age 29
- 13Dose & timingDose unconfirmed Daily · Weekly
mTOR inhibitor — caloric restriction mimetic (recent addition)
02Citations
- 01Lifespan Podcast Ep.3Nicotinamide Mononucleotide (NMN)
- 02NOVOS analysisTMG (Trimethylglycine)
- 03omre.co (2025)Taurine
- 04Joe Rogan #1349Statin (high dose)
03Edit history
- v1Current versionFebruary 18, 2026