Dr. Mark Hyman's Core Supplement Stack
Supplement Protocol · 12 interventions
Comprehensive supplement protocol for longevity, metabolic health, and optimal function. Emphasizes high-quality, bioavailable forms.
Supplements
12 interventions- 01Dose & timing2-6 capsules Daily with meals
Foundation supplement - safety net for nutritional gaps
- 02Dose & timing900mg Daily
NAD+ production for cellular energy and longevity
- 03Dose & timing2,000-5,000 IU Daily
Immune function, metabolic health, hormone balance. Adjust based on blood levels.
- 04Dose & timing500-1,000mg EPA/DHA Daily
Heart health, brain function, inflammation control
- 05Dose & timing200-400mg Daily or evening
Powers 600+ enzymatic reactions, sleep, muscle function
- 06Dose & timing5-10 billion CFU Daily
Gut health, immune support, metabolic function
- 07Dose & timing3-5g Daily
Muscle preservation and cognitive support
- 08Dose & timing200mg Daily
Cellular energy production and heart health
- 09Dose & timing500-1,000mg Daily
Anti-inflammatory, joint support, liver function
- 10Dose & timing300-600mg Daily (split doses)
Blood sugar regulation, antioxidant, liver support
- 11Dose & timing4-12mg Daily
Powerful antioxidant for cellular protection and longevity
- 12Dose & timing2 capsules Daily with meals
Homocysteine control, methylation support, energy
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- v1Current versionFebruary 22, 2026